CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Revenue:
Total revenue	$ 71,857	$ 73,414	$ 60,370
Costs and expenses:
Cost of goods sold			715
Research and development (1)	260,953	219,248	201,348
Selling, general and administrative (1)	108,661	106,081	97,058
Total costs and expenses	369,614	325,329	299,121
Loss from operations	(297,757)	(251,915)	(238,751)
Income from investment in TRC, LLC	68,438	33,705	11,182
Interest expense	(44,585)	(31,862)	(10,482)
Loss on extinguishment of debt	(15,464)
Interest and other income, net	2,831	8,395	11,966
Loss before income taxes	(286,537)	(241,677)	(226,085)
Provision for income tax benefit	8,520	5,222	10,561
Net loss	$ (278,017)	$ (236,455)	$ (215,524)
Net loss per share:
Basic and diluted net loss per share (in dollars per share)	$ (4.46)	$ (4.25)	$ (3.99)
Shares used to compute basic and diluted net loss per share (in shares)	62,345	55,610	53,969
Total share-based compensation expense	$ 62,976	$ 60,450	$ 51,313
Research and development
Net loss per share:
Total share-based compensation expense	31,294	28,953	25,563
Selling, general and administrative
Net loss per share:
Total share-based compensation expense	31,682	31,497	25,750
Product sales
Revenue:
Total revenue			15,304
Collaborative revenue
Revenue:
Total revenue	26,464	31,250	41,791
Licensing revenue
Revenue:
Total revenue	1,500	28,500
Viatris collaboration agreement
Revenue:
Total revenue	$ 43,893	$ 13,664	$ 3,275