Organization and Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2020

Organization and Summary of Significant Accounting Policies

Schedule of property and equipment useful lives

Leasehold improvements	Shorter of remaining lease terms or useful life
Equipment, furniture and fixtures	5 - 7 years
Software and computer equipment	3 - 5 years

Schedule of basic and diluted net loss per share

	Year Ended December 31,
(In thousands, except per share data)	2020		2019		2018
Numerator:
Net loss	$	(278,017)	$	(236,455)	$	(215,524)
Denominator:
Weighted-average ordinary shares outstanding		62,808		56,452		55,076
Less: weighted-average ordinary shares subject to forfeiture		(463)		(842)		(1,107)
Weighted-average ordinary shares used to compute basic and diluted net loss per share		62,345		55,610		53,969
Basic and diluted net loss per share	$	(4.46)	$	(4.25)	$	(3.99)

Schedule of anti-dilutive securities

	Year Ended December 31,
(In thousands)	2020	2019	2018
Share issuances under equity incentive plans and ESPP	6,553	6,577	3,492
Restricted shares	—	—	2
Share issuances upon the conversion of convertible senior notes	6,676	6,676	6,676
Total	13,229	13,253	10,170