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Share-Based Compensation - Performance Contingent Awards (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended 12 Months Ended
Jun. 30, 2020
Jun. 30, 2019
Jun. 30, 2020
Jun. 30, 2019
Dec. 31, 2016
Share-Based Compensation          
Share-based compensation expense $ 16,585 $ 11,298 $ 31,861 $ 23,519  
Research and development          
Share-Based Compensation          
Share-based compensation expense 8,098 5,720 15,963 11,880  
Selling, general and administrative          
Share-Based Compensation          
Share-based compensation expense $ 8,487 $ 5,578 $ 15,898 $ 11,639  
Performance-Contingent Awards - RSAs          
Share-Based Compensation          
Shares approved for grant (in shares)         1,575,000
Vesting period         5 years
Awards outstanding (in shares) 414,000 877,500 414,000 877,500  
Performance-Contingent Awards - RSUs          
Share-Based Compensation          
Awards outstanding (in shares) 54,000 101,250 54,000 101,250  
Share-based compensation expense     $ 700    
Performance-Contingent Awards - RSUs | Senior management          
Share-Based Compensation          
Shares approved for grant (in shares)         135,000
Performance-Contingent Awards - RSUs          
Share-Based Compensation          
Awards outstanding (in shares) 120,000   120,000    
Share-based compensation expense $ 500        
Maximum potential expense | Performance-Contingent Awards - RSUs          
Share-Based Compensation          
Share-based compensation expense     $ 1,800    
Second tranche          
Share-Based Compensation          
Share-based compensation expense   $ (300) 400 $ 500  
Third tranche          
Share-Based Compensation          
Share-based compensation expense $ 600   1,300    
Third tranche | Maximum potential expense          
Share-Based Compensation          
Share-based compensation expense     1,700    
Third tranche | Maximum potential expense | Research and development          
Share-Based Compensation          
Share-based compensation expense     600    
Third tranche | Maximum potential expense | Selling, general and administrative          
Share-Based Compensation          
Share-based compensation expense     $ 1,100