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Share-Based Compensation - Expense (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2020
Jun. 30, 2019
Jun. 30, 2020
Jun. 30, 2019
Share-Based Compensation        
Share-based compensation expense $ 16,585 $ 11,298 $ 31,861 $ 23,519
Research and development        
Share-Based Compensation        
Share-based compensation expense 8,098 5,720 15,963 11,880
Selling, general and administrative        
Share-Based Compensation        
Share-based compensation expense $ 8,487 $ 5,578 $ 15,898 $ 11,639