CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2020	Mar. 31, 2019
Revenue:
Revenue	$ 19,862	$ 5,338
Costs and expenses:
Research and development	66,013	53,818
Selling, general and administrative	26,325	25,186
Total costs and expenses	92,338	79,004
Loss from operations	(72,476)	(73,666)
Income from investment in TRC, LLC	13,515	6,229
Interest expense	(9,941)	(7,858)
Loss on extinguishment of debt	(15,464)
Interest and other income, net	1,460	2,795
Loss before income taxes	(82,906)	(72,500)
Provision for income tax expense	(147)	(80)
Net loss	(83,053)	(72,580)
Net unrealized gain on available-for-sale investments	367	130
Total comprehensive loss	$ (82,686)	$ (72,450)
Net loss per share:
Basic and diluted net loss per share (in dollars per share)	$ (1.40)	$ (1.32)
Shares used to compute basic and diluted net loss per share (in shares)	59,463	54,938
Share-based compensation expense	$ 15,276	$ 12,220
Research and development
Net loss per share:
Share-based compensation expense	7,865	6,159
Selling, general and administrative
Net loss per share:
Share-based compensation expense	7,411	6,061
Collaborative revenue
Revenue:
Revenue	6,632	$ 5,338
Licensing revenue
Revenue:
Revenue	1,500
Mylan collaboration agreement
Revenue:
Revenue	$ 11,730