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Share-Based Compensation - Performance Contingent Awards (Details) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Mar. 31, 2020
Mar. 31, 2019
Dec. 31, 2016
Share-Based Compensation      
Share-based compensation expense $ 15,276 $ 12,220  
Research and development      
Share-Based Compensation      
Share-based compensation expense 7,865 6,159  
Selling, general and administrative      
Share-Based Compensation      
Share-based compensation expense $ 7,411 $ 6,061  
Performance-Contingent Awards - RSAs      
Share-Based Compensation      
Shares approved for grant (in shares)     1,575,000
Vesting period     5 years
Awards outstanding (in shares) 414,000 877,500  
Performance-Contingent Awards - RSUs      
Share-Based Compensation      
Awards outstanding (in shares) 54,000 101,250  
Performance-Contingent Awards - RSUs | Senior management      
Share-Based Compensation      
Shares approved for grant (in shares)     135,000
Performance-Contingent Awards - RSUs      
Share-Based Compensation      
Awards outstanding (in shares) 120,000    
Share-based compensation expense $ 200    
Maximum potential expense | Performance-Contingent Awards - RSUs      
Share-Based Compensation      
Share-based compensation expense 2,300    
Second tranche      
Share-Based Compensation      
Share-based compensation expense 400 $ 800  
Third tranche      
Share-Based Compensation      
Share-based compensation expense 600    
Third tranche | Maximum potential expense      
Share-Based Compensation      
Share-based compensation expense 2,300    
Third tranche | Maximum potential expense | Research and development      
Share-Based Compensation      
Share-based compensation expense 800    
Third tranche | Maximum potential expense | Selling, general and administrative      
Share-Based Compensation      
Share-based compensation expense $ 1,500