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Revenue - Development and Commercialization Agreement (Details)
$ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended 24 Months Ended
Dec. 31, 2019
USD ($)
plan
Jun. 30, 2019
USD ($)
Feb. 28, 2018
Jan. 31, 2015
plan
Mar. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
Mar. 31, 2019
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Dec. 31, 2016
USD ($)
Collaborative Arrangements and Co-Promote Agreement                    
Milestone payment         $ 19,862   $ 5,338      
Percentage of profit share     33.00%   35.00%          
Mylan                    
Collaborative Arrangements and Co-Promote Agreement                    
Upfront payment receivable   $ 18,500                
Potential milestone or contingent payments         $ 1,500          
Transaction price         $ 34,200          
Number of performance obligations | plan       2            
Performance period (in years)       17 years 12 years          
Deferred revenue         $ 300          
Percentage of profit share         65.00%          
Mylan | Purchase Agreement                    
Collaborative Arrangements and Co-Promote Agreement                    
Premium proceeds from sale of ordinary shares         $ 4,200          
Mylan | Development and Commercialization Agreement                    
Collaborative Arrangements and Co-Promote Agreement                    
Initial cash payment                 $ 15,000 $ 30,000
Milestone payment                 $ 15,000  
Mylan | Future potential combination products                    
Collaborative Arrangements and Co-Promote Agreement                    
Potential milestone or contingent payments   $ 7,500     45,000          
Mylan | Milestone - 50% enrollment in Phase 3 twelve-month safety study | Collaborative Arrangement                    
Collaborative Arrangements and Co-Promote Agreement                    
Milestone payment               $ 15,000    
Mylan | Sales milestones                    
Collaborative Arrangements and Co-Promote Agreement                    
Potential milestone or contingent payments         $ 150,000          
Pfizer                    
Collaborative Arrangements and Co-Promote Agreement                    
Upfront payment receivable $ 10,000         $ 10,000        
Number of performance obligations | plan 2                  
Pfizer | Sales milestones                    
Collaborative Arrangements and Co-Promote Agreement                    
Milestone payment $ 240,000