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Share-Based Compensation - Performance Contingent Awards (Details) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Sep. 25, 2015
Aug. 28, 2015
Mar. 31, 2016
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Share-Based Compensation            
Vesting period 3 years          
Share-based compensation expense       $ 60,450 $ 51,313 $ 49,145
Research and development            
Share-Based Compensation            
Share-based compensation expense       28,953 25,563 22,691
Selling, general and administrative            
Share-Based Compensation            
Share-based compensation expense       $ 31,497 $ 25,750 26,454
Performance-Contingent Awards - RSAs            
Share-Based Compensation            
Shares approved for grant (in shares)     1,575,000      
Awards outstanding (in shares)       776,250 978,750  
Performance-Contingent Awards - RSUs            
Share-Based Compensation            
Shares approved for grant (in shares)     135,000      
Awards outstanding (in shares)       101,250 101,250  
Performance-based vesting            
Share-Based Compensation            
Vesting period     5 years      
RSUs            
Share-Based Compensation            
Vesting period     5 years      
Awards outstanding (in shares)       4,939,774 3,069,403  
Share-based compensation expense       $ 39,520 $ 34,077 25,959
RSUs | Minimum            
Share-Based Compensation            
Vesting period   3 years        
RSUs | Maximum            
Share-Based Compensation            
Vesting period   4 years        
Maximum potential expense | Research and development            
Share-Based Compensation            
Share-based compensation expense       100    
Maximum potential expense | Selling, general and administrative            
Share-Based Compensation            
Share-based compensation expense       300    
First tranche            
Share-Based Compensation            
Share-based compensation expense         1,700 2,600
Second tranche            
Share-Based Compensation            
Share-based compensation expense       1,900 $ 2,600 $ 6,300
Third tranche            
Share-Based Compensation            
Share-based compensation expense       9,800    
Third tranche | Research and development            
Share-Based Compensation            
Share-based compensation expense       1,000    
Third tranche | Selling, general and administrative            
Share-Based Compensation            
Share-based compensation expense       1,900    
Third tranche | Maximum potential expense            
Share-Based Compensation            
Share-based compensation expense       2,900    
Second and Third tranche            
Share-Based Compensation            
Share-based compensation expense       $ 400