CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Revenue:
Revenue	$ 73,414	$ 60,370	$ 15,386
Costs and expenses:
Cost of goods sold		715	6,030
Research and development	219,248	201,348	173,887
Selling, general and administrative	106,081	97,058	95,592
Total costs and expenses	325,329	299,121	275,509
Loss from operations	(251,915)	(238,751)	(260,123)
Income from investment in TRC, LLC	33,705	11,182	170
Interest expense	(31,862)	(10,482)	(8,547)
Other-than-temporary impairment loss			(8,000)
Interest and other income, net	8,395	11,966	4,789
Loss before income taxes	(241,677)	(226,085)	(271,711)
Provision for income tax benefit (expense)	5,222	10,561	(13,694)
Net loss	$ (236,455)	$ (215,524)	$ (285,405)
Net loss per share:
Basic and diluted net loss per share (in dollars per share)	$ (4.25)	$ (3.99)	$ (5.45)
Shares used to compute basic and diluted net loss per share (in shares)	55,610	53,969	52,352
Share-based compensation expense	$ 60,450	$ 51,313	$ 49,145
Research and development
Net loss per share:
Share-based compensation expense	28,953	25,563	22,691
Selling, general and administrative
Net loss per share:
Share-based compensation expense	31,497	25,750	26,454
Product sales
Revenue:
Revenue		15,304	14,788
Collaborative revenue
Revenue:
Revenue	31,250	41,791	$ 598
Licensing revenue
Revenue:
Revenue	28,500
Mylan collaboration agreement
Revenue:
Revenue	$ 13,664	$ 3,275