CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
Sep. 30, 2019	Sep. 30, 2018
Operating activities
Net loss	$ (170,849)	$ (165,338)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	4,676	3,195
Amortization and accretion income, net	(2,599)	(887)
Share-based compensation	36,538	39,599
Reversal of inventory purchase commitment liability		(2,250)
Amortization of right-of-use assets	3,029
Undistributed earnings from investment in TRC, LLC	(11,239)	(2,803)
Other	148	(68)
Changes in operating assets and liabilities:
Accounts receivable	534	(771)
Receivables from collaborative arrangements	5,458	3,202
Other prepaid and current assets	(681)	(493)
Inventories		(552)
Tax receivable	(3,700)	5,092
Other assets	3	(115)
Accounts payable	(543)	(1,665)
Accrued personnel-related expenses, accrued clinical and development expenses, and other accrued liabilities	(9,846)	(14,324)
Accrued interest payable	4,482
Deferred rent		3,370
Deferred revenue	(21,661)	79,266
Long-term portion of lease liabilities	(2,307)
Other long-term liabilities	(5,288)	(5,147)
Net cash used in operating activities	(173,845)	(60,689)
Investing activities
Purchases of property and equipment	(1,873)	(5,740)
Purchases of marketable securities	(366,412)	(166,412)
Maturities of marketable securities	266,168	249,450
Proceeds from the sale of VIBATIV business, net	5,000
Proceeds from the sale of fixed assets	5	17
Net cash (used in) provided by investing activities	(97,112)	77,315
Financing activities
Proceeds from ESPP purchases	2,605	2,742
Proceeds from option exercises	2,973	1,306
Repurchase of shares to satisfy tax withholding	(2,743)	(8,452)
Net cash provided by (used in) financing activities	2,835	(4,404)
Net (decrease) increase in cash, cash equivalents, and restricted cash	(268,122)	12,222
Cash, cash equivalents, and restricted cash at beginning of period	378,854	89,813
Cash, cash equivalents, and restricted cash at end of period	110,732	102,035
Supplemental disclosure of cash flow information
Cash paid for interest	17,097	3,738
Cash paid (received) for income taxes, net	22	$ (5,027)
Right-of-use assets obtained in exchange for lease obligations (1)	$ 49,847

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The cash inflow from the sale of property, plant and equipment (capital expenditures), software, and other intangible assets.

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Amount of cash inflow from exercise of option under share-based payment arrangement.

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The cash inflow associated with the amount received from the stock plan during the period.

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Amount of increase in right-of-use asset obtained in exchange for operating lease liability.

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Amount of noncash expense for share-based payment arrangement.

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