CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Revenue:
Revenue	$ 12,427,000	$ 12,838,000	$ 43,915,000	$ 44,633,000
Costs and expenses:
Cost of goods sold		705,000		83,000
Research and development	52,006,000	52,693,000	152,223,000	149,079,000
Selling, general and administrative	25,622,000	21,890,000	73,035,000	71,601,000
Total costs and expenses	77,628,000	75,288,000	225,258,000	220,763,000
Loss from operations	(65,201,000)	(62,450,000)	(181,343,000)	(176,130,000)
Income from investment in TRC, LLC	7,197,000	3,119,000	21,792,000	5,754,000
Interest expense	(8,068,000)	(2,137,000)	(23,827,000)	(6,411,000)
Interest and other income, net	2,089,000	1,376,000	7,258,000	4,144,000
Loss before income taxes	(63,983,000)	(60,092,000)	(176,120,000)	(172,643,000)
Provision for income tax benefit	5,552,000	659,000	5,271,000	7,305,000
Net loss	(58,431,000)	(59,433,000)	(170,849,000)	(165,338,000)
Net unrealized (loss) gain on available-for-sale investments	(35,000)	194,000	260,000	402,000
Total comprehensive loss	$ (58,466,000)	$ (59,239,000)	$ (170,589,000)	$ (164,936,000)
Net loss per share:
Basic and diluted net loss per share (in dollars per share)	$ (1.05)	$ (1.10)	$ (3.08)	$ (3.07)
Shares used to compute basic and diluted net loss per share (in shares)	55,858	54,248	55,445	53,771
Share-based compensation expense	$ 13,019,000	$ 11,746,000	$ 36,538,000	$ 39,599,000
Research and development
Net loss per share:
Share-based compensation expense	6,458,000	6,294,000	18,338,000	19,757,000
Selling, general and administrative
Net loss per share:
Share-based compensation expense	6,561,000	5,452,000	18,200,000	19,842,000
Product
Revenue:
Revenue		3,849,000		12,889,000
Collaborative revenue
Revenue:
Revenue	8,836,000	$ 8,989,000	21,666,000	$ 31,744,000
Licensing revenue
Revenue:
Revenue			18,500,000
Mylan collaroration agreement
Revenue:
Revenue	$ 3,591,000		$ 3,749,000