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Revenue - Development and Commercialization Agreement (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended
Jan. 30, 2015
Feb. 28, 2018
Sep. 30, 2019
Sep. 30, 2018
Sep. 30, 2019
Sep. 30, 2018
Dec. 31, 2016
Dec. 31, 2015
Jan. 31, 2015
Collaborative Arrangements and Co-Promote Agreement                  
Milestone payment     $ 12,427 $ 12,838 $ 43,915 $ 44,633      
Percentage of profit share   67.00%     65.00%        
Revenue from the recognition of previously deferred revenue     8,836 7 $ 21,661 39      
Mylan                  
Collaborative Arrangements and Co-Promote Agreement                  
Initial cash payment               $ 15,000  
Number of shares purchased 1,585,790                
Potential milestone or contingent payments                 $ 205,000
Transaction price               $ 34,200  
Percentage of profit share         35.00%        
Performance period (in years)         12 years     17 years  
Deferred revenue     300   $ 300        
Mylan | Purchase Agreement                  
Collaborative Arrangements and Co-Promote Agreement                  
Equity investments made in the entity $ 30,000                
Share Price $ 18.918                
Price per share premium (as a percent) 10.00%                
Premium proceeds from sale of ordinary shares $ 4,200             $ 4,200  
Mylan | Future potential combination products                  
Collaborative Arrangements and Co-Promote Agreement                  
Initial cash payment               15,000  
Potential milestone or contingent payments     7,500   7,500       $ 45,000
Mylan | Milestone - 50% enrollment in Phase 3 twelve-month safety study                  
Collaborative Arrangements and Co-Promote Agreement                  
Milestone payment             $ 15,000    
Mylan | Milestone - 50% enrollment in Phase 3 twelve-month safety study | Development and Commercialization Agreement                  
Collaborative Arrangements and Co-Promote Agreement                  
Initial cash payment               $ 15,000  
Alfasigma                  
Collaborative Arrangements and Co-Promote Agreement                  
Milestone payment     $ 23 $ 117 $ 121 $ 10,650