Revenue - Janssen Biotech Agreement (Details) - USD ($) $ in Thousands	1 Months Ended	3 Months Ended	9 Months Ended
Feb. 28, 2018	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Collaborative Arrangements and Co-Promote Agreement
Revenue		$ 12,427	$ 12,838	$ 43,915	$ 44,633
Percentage of profit share	67.00%			65.00%
Revenue from the recognition of previously deferred revenue		8,836	7	$ 21,661	39
Research and development		52,006	52,693	152,223	149,079
Janssen
Collaborative Arrangements and Co-Promote Agreement
Upfront payment receivable	$ 100,000
Revenue		8,807	8,866	21,522	21,044
Percentage of profit share	33.00%
Maximum potential payments receivable	$ 900,000
Collaborative arrangement, opt in fee	200,000
Collaborative arrangement, future development and commercialization milestones	$ 700,000
Revenue from collaborative arrangements		8,800		21,500
Research and development		11,500	$ 10,500	29,100	$ 28,100
Deferred revenue		$ 47,400		$ 47,400

The amount of maximum potential payments receivable under the collaboration arrangement.

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The amount of upfront payments receivable under the collaboration arrangement.

+ References

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Represents the amount of future development and commercialization milestones under the collaborative arrangements.

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Represents the amount of opt in fee under the collaborative arrangements.

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Revenue earned under collaborative arrangements from upfront payments and contingent payments.

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Represents the percentage of profit or loss sharing arrangement as per collaboration agreement.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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Amount of obligation to transfer good or service to customer for which consideration has been received or is receivable.

+ References

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Amount of revenue recognized that was previously included in balance of obligation to transfer good or service to customer for which consideration from customer has been received or is due.

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.

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