CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Sep. 30, 2019	Dec. 31, 2018
Current assets:
Cash and cash equivalents	$ 102,403	$ 378,021
Short-term marketable securities	217,278	127,255
Accounts receivable, net of allowances of $0 at September 30, 2019 and December 31, 2018	87	620
Receivables from collaborative arrangements	4,595	10,053
Amounts due from TRC, LLC	16,661	5,422
Short-term restricted cash	7,496
Other prepaid and current assets	7,132	11,452
Total current assets	355,652	532,823
Property and equipment, net	12,189	13,176
Long-term marketable securities	24,939	11,869
Operating lease assets	46,755
Tax receivable	3,664
Restricted cash	833	833
Other assets	1,305	1,534
Total assets	445,337	560,235
Current liabilities:
Accounts payable	8,713	9,028
Accrued personnel-related expenses	25,801	23,803
Accrued clinical and development expenses	10,907	11,876
Accrued interest payable	7,568	3,086
Non-recourse notes due 2033, net	8,701
Operating lease liabilities	6,833
Deferred revenue	33,751	43,402
Other accrued liabilities	6,549	7,359
Total current liabilities	108,823	98,554
Convertible senior notes due 2023, net	225,622	224,818
Non-recourse notes due 2033, net	222,008	229,535
Deferred rent		7,976
Long-term operating lease liabilities	48,620
Long-term deferred revenue	14,169	26,179
Other long-term liabilities	8,900	24,762
Commitments and contingencies
Shareholders' Deficit
Preferred shares, $0.00001 par value: 230 shares authorized, no shares issued or outstanding	0	0
Ordinary shares, $0.00001 par value: 200,000 shares authorized; 56,762 and 55,681 shares issued and outstanding at September 30, 2019 and December 31, 2018, respectively	1	1
Additional paid-in capital	1,000,094	960,721
Accumulated other comprehensive income (loss)	94	(166)
Accumulated deficit	(1,182,994)	(1,012,145)
Total shareholders' deficit	(182,805)	(51,589)
Total liabilities and shareholders' deficit	$ 445,337	$ 560,235