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Commitments and Contingencies - Operating Leases and Subleases (Details)
$ in Thousands
12 Months Ended
Dec. 31, 2018
USD ($)
ft²
item
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Future minimum lease payments      
2019 $ 7,817    
2020 6,547    
2021 9,501    
2022 9,766    
Thereafter 80,281    
Total $ 113,912    
United States      
Operating Leases and Subleases      
Square feet of office and laboratory space | ft² 170,000    
Number of buildings | item 2    
Ireland      
Operating Leases and Subleases      
Square feet of office and laboratory space | ft² 6,100    
Operating Leases      
Future minimum lease payments      
Rent expense, net $ 9,965 $ 7,740 $ 6,865
Sublease income $ 73 $ 209 $ 244