Income Taxes - Deferred income taxes (Details) - USD ($) $ in Thousands	Dec. 31, 2018	Dec. 31, 2017
Components of Deferred Tax Assets [Abstract]
Net operating loss carryforwards	$ 33,396	$ 15,834
Capital loss carryforwards	19,409	0
Research and development tax credit carryforwards	8,508	6,504
Fixed assets and intangibles	285,821	3,746
Share-based compensation	12,479	11,140
Accruals	8,343	5,293
Other	0	248
Subtotal	367,956	42,765
Valuation allowance	(367,748)	(42,613)
Total deferred tax assets	208	152
Deferred tax liabilities:
Prepaid assets	(208)	(152)
Total deferred tax liabilities	(208)	(152)
Deferred Tax Assets, Net	0	$ 0
Information related to valuation allowance
Deferred tax asset, intellectual property	282,700
Operating loss	56,900
Ireland
Information related to valuation allowance
Net operating loss carryforwards	210,700
Capital loss carryforwards | Ireland
Information related to valuation allowance
Tax credit carryforward amount	58,800
Federal
Information related to valuation allowance
Net operating loss carryforwards	101,800
Federal | Research and Development
Information related to valuation allowance
Tax credit carryforward amount	10,600
State
Information related to valuation allowance
Net operating loss carryforwards	76,600
State | Research and Development
Information related to valuation allowance
Tax credit carryforward amount	$ 13,300