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Share-Based Compensation - Performance Contingent Awards (Details)
$ in Thousands
3 Months Ended 12 Months Ended
Sep. 25, 2015
Aug. 28, 2015
Mar. 31, 2016
shares
Dec. 31, 2018
USD ($)
tranche
shares
Dec. 31, 2017
USD ($)
tranche
shares
Dec. 31, 2016
USD ($)
shares
Dec. 31, 2015
shares
Share-Based Compensation              
Vesting period 3 years            
Number of tranches | tranche       3 2    
Share-based compensation expense       $ 51,313 $ 49,145 $ 41,169  
Research and development              
Share-Based Compensation              
Share-based compensation expense       25,563 22,691 20,202  
Selling, general and administrative              
Share-Based Compensation              
Share-based compensation expense       $ 25,750 $ 26,454 $ 20,967  
Performance-Contingent Awards - RSAs              
Share-Based Compensation              
Shares approved for grant (in shares) | shares     1,575,000        
Awards outstanding (in shares) | shares       978,750 1,305,000 1,440,000 0
Performance-Contingent Awards - RSAs | Senior management              
Share-Based Compensation              
Share-based compensation expense         $ 1,000    
Performance-Contingent Awards - RSUs              
Share-Based Compensation              
Shares approved for grant (in shares) | shares     135,000   50,000    
Awards outstanding (in shares) | shares       101,250 135,000    
Performance-based vesting              
Share-Based Compensation              
Vesting period     5 years        
RSUs              
Share-Based Compensation              
Vesting period     5 years        
Awards outstanding (in shares) | shares       3,069,403 2,897,758 3,609,118 2,988,041
Share-based compensation expense       $ 34,077 $ 25,959 $ 20,946  
RSUs | Minimum              
Share-Based Compensation              
Vesting period   3 years          
Maximum potential expense | Research and development              
Share-Based Compensation              
Share-based compensation expense       7,400      
Maximum potential expense | Selling, general and administrative              
Share-Based Compensation              
Share-based compensation expense       10,400      
First tranche              
Share-Based Compensation              
Share-based compensation expense       1,700 2,600    
First tranche | Performance-Contingent Awards - RSUs              
Share-Based Compensation              
Share-based compensation expense       400 400    
First tranche | Maximum potential expense | Performance-Contingent Awards - RSUs              
Share-Based Compensation              
Share-based compensation expense         800    
Second tranche              
Share-Based Compensation              
Share-based compensation expense       2,600 $ 6,300    
Third tranche              
Share-Based Compensation              
Share-based compensation expense       0      
Second and Third tranche              
Share-Based Compensation              
Share-based compensation expense       $ 17,800