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Collaborative Arrangementt - Development and Commercialization Agreement (Details)
1 Months Ended 3 Months Ended 12 Months Ended
Jan. 30, 2015
Apr. 30, 2018
plan
Feb. 28, 2018
Feb. 28, 2015
USD ($)
$ / shares
shares
Jan. 31, 2015
USD ($)
plan
Dec. 31, 2018
USD ($)
Sep. 30, 2018
USD ($)
Jun. 30, 2018
USD ($)
Mar. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Sep. 30, 2017
USD ($)
Jun. 30, 2017
USD ($)
Mar. 31, 2017
USD ($)
Dec. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Collaborative Arrangements and Co-Promote Agreement                                  
Milestone payment           $ 15,737,000 $ 12,838,000 $ 23,476,000 $ 8,319,000 $ 4,515,000 $ 4,275,000 $ 3,509,000 $ 3,087,000 $ 60,370,000 $ 15,386,000 $ 48,648,000  
Equity investments made in the entity                             1,000 253,028,000  
Percentage of profit share     33.00%                     35.00%      
Expense on collaboration agreement           78,358,000 $ 75,288,000 $ 72,180,000 $ 73,295,000 $ 83,691,000 $ 61,272,000 $ 68,630,000 $ 61,916,000 $ 299,121,000 275,509,000 229,115,000  
Revenue from the recognition of previously deferred revenue                           130,000      
Mylan                                  
Collaborative Arrangements and Co-Promote Agreement                                  
Milestone payment                           24,000 $ 102,000 15,102,000  
Potential milestone or contingent payments           205,000,000               $ 205,000,000      
Transaction price         $ 34,200,000                        
Number of performance obligations | plan         2                        
Percentage of profit share                           (65.00%)      
Performance period (n years)         17 years                 14 years      
Deferred revenue           300,000               $ 300,000      
Revenue from the recognition of previously deferred revenue                           24,000      
Mylan | Purchase Agreement                                  
Collaborative Arrangements and Co-Promote Agreement                                  
Equity investments made in the entity       $ 30,000,000                          
Number of shares purchased | shares       1,585,790                          
Share Price | $ / shares       $ 18.918                          
Price per share premium (as a percent)       10.00%                          
Premium proceeds from sale of ordinary shares       $ 4,200,000                          
Trading days 5 days                                
Mylan | Development and Commercialization Agreement                                  
Collaborative Arrangements and Co-Promote Agreement                                  
Initial cash payment                                 $ 15,000,000
Mylan | Revefenacin Monotherapy (TD-4208)                                  
Collaborative Arrangements and Co-Promote Agreement                                  
Potential milestone or contingent payments           160,000,000               160,000,000      
Mylan | Future potential combination products                                  
Collaborative Arrangements and Co-Promote Agreement                                  
Potential milestone or contingent payments           45,000,000               45,000,000      
Mylan | Milestone - 50% enrollment in Phase 3 twelve-month safety study | Collaborative Arrangement                                  
Collaborative Arrangements and Co-Promote Agreement                                  
Milestone payment                               15,000,000  
Mylan | Sales milestones | Revefenacin Monotherapy (TD-4208)                                  
Collaborative Arrangements and Co-Promote Agreement                                  
Potential milestone or contingent payments           150,000,000               150,000,000      
Mylan | Regulatory actions | Revefenacin Monotherapy (TD-4208) | European Union                                  
Collaborative Arrangements and Co-Promote Agreement                                  
Potential milestone or contingent payments           $ 10,000,000               10,000,000      
Takeda                                  
Collaborative Arrangements and Co-Promote Agreement                                  
Milestone payment                               15,075,000  
Revenue from the recognition of previously deferred revenue                               $ 15,100,000  
Alfasigma                                  
Collaborative Arrangements and Co-Promote Agreement                                  
Milestone payment                           $ 10,678,000      
Number of performance obligations | plan   5