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Collaborative Arrangements - Development and Collaboration Agreement (Details)
$ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended
Apr. 30, 2018
USD ($)
Jan. 31, 2015
plan
Dec. 31, 2018
USD ($)
Sep. 30, 2018
USD ($)
Jun. 30, 2018
USD ($)
Mar. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Sep. 30, 2017
USD ($)
Jun. 30, 2017
USD ($)
Mar. 31, 2017
USD ($)
Dec. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Development and Collaboration Agreement                          
Revenue     $ 15,737 $ 12,838 $ 23,476 $ 8,319 $ 4,515 $ 4,275 $ 3,509 $ 3,087 $ 60,370 $ 15,386 $ 48,648
Alfasigma                          
Development and Collaboration Agreement                          
Deferred revenue     300               $ 300    
Performance period (n years)                     4 years    
Mylan                          
Development and Collaboration Agreement                          
Revenue                     $ 24 $ 102 $ 15,102
Deferred revenue     $ 300               $ 300    
Performance period (n years)   17 years                 14 years    
Number of performance obligations | plan   2                      
Development and Collaboration Agreement | Alfasigma                          
Development and Collaboration Agreement                          
Maximum potential payments receivable                     $ 26,800    
Transaction price $ 11,000                        
Option exercise fee 10,000                        
Non-refundable reimbursement fee $ 1,000                        
Development and Commercialization Agreement | Alfasigma                          
Development and Collaboration Agreement                          
Revenue                     $ 10,700