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Collaborative Arrangements - Janssen Biotech Agreement (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended
Feb. 28, 2018
Jun. 30, 2016
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Collaborative Arrangements and Co-Promote Agreement                          
Revenue     $ 15,737 $ 12,838 $ 23,476 $ 8,319 $ 4,515 $ 4,275 $ 3,509 $ 3,087 $ 60,370 $ 15,386 $ 48,648
Percentage of profit share 33.00%                   35.00%    
Revenue from the recognition of previously deferred revenue                     $ 130    
Research and development                     201,348 $ 173,887 141,712
Takeda                          
Collaborative Arrangements and Co-Promote Agreement                          
Revenue                         15,075
Revenue from collaborative arrangements   $ 15,000                      
Revenue from the recognition of previously deferred revenue                         $ 15,100
Janssen                          
Collaborative Arrangements and Co-Promote Agreement                          
Upfront payment receivable $ 100,000                        
Revenue                     31,053    
Percentage of profit share 67.00%                        
Maximum potential payments receivable $ 900,000                        
Revenue from collaborative arrangements                     31,100    
Revenue from the recognition of previously deferred revenue 68,900                        
Research and development                     $ 38,600    
Janssen | Collaborative Arrangement                          
Collaborative Arrangements and Co-Promote Agreement                          
Revenue 700,000                        
Janssen | Collaborative Arrangement | TD-1473                          
Collaborative Arrangements and Co-Promote Agreement                          
Revenue $ 200,000