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Collaborative Arrangements - Revenue from Collaborative Arrangements (Details) - USD ($)
1 Months Ended 3 Months Ended 12 Months Ended
Feb. 28, 2018
Jun. 30, 2016
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Collaborative Arrangements and Co-Promote Agreement                          
Revenue     $ 15,737,000 $ 12,838,000 $ 23,476,000 $ 8,319,000 $ 4,515,000 $ 4,275,000 $ 3,509,000 $ 3,087,000 $ 60,370,000 $ 15,386,000 $ 48,648,000
Collaboration revenue recognized in the period from:                          
Amounts included in deferred revenue at the beginning of the period                     130,000    
Janssen                          
Collaborative Arrangements and Co-Promote Agreement                          
Revenue                     31,053,000    
Total revenue from collaborative arrangements                     31,100,000    
Collaboration revenue recognized in the period from:                          
Amounts included in deferred revenue at the beginning of the period $ 68,900,000                        
Alfasigma                          
Collaborative Arrangements and Co-Promote Agreement                          
Revenue                     10,678,000    
Mylan                          
Collaborative Arrangements and Co-Promote Agreement                          
Revenue                     24,000 102,000 15,102,000
Collaboration revenue recognized in the period from:                          
Amounts included in deferred revenue at the beginning of the period                     24,000    
R-Pharm                          
Collaborative Arrangements and Co-Promote Agreement                          
Revenue                     32,000 491,000 109,000
Takeda                          
Collaborative Arrangements and Co-Promote Agreement                          
Revenue                         15,075,000
Total revenue from collaborative arrangements   $ 15,000,000                      
Collaboration revenue recognized in the period from:                          
Amounts included in deferred revenue at the beginning of the period                         15,100,000
Various VIBATIV collaborative partners                          
Collaborative Arrangements and Co-Promote Agreement                          
Revenue                     4,000 5,000 259,000
Other                          
Collaborative Arrangements and Co-Promote Agreement                          
Revenue                         500,000
Collaborative revenue                          
Collaborative Arrangements and Co-Promote Agreement                          
Revenue                     41,791,000 $ 598,000 $ 31,045,000
Profit sharing revenue                          
Collaborative Arrangements and Co-Promote Agreement                          
Revenue                     3,275,000    
Profit sharing revenue | Mylan                          
Collaborative Arrangements and Co-Promote Agreement                          
Revenue                     $ 3,300,000