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Organization and Summary of Significant Accounting Policies - Related Parties (Details) - USD ($) $ in Thousands		12 Months Ended
	Mar. 17, 2016	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Related party transactions
Ordinary shares held (in percent)		85.00%
Proceeds from sale of ordinary shares, net				$ 253,028
GSK
Related party transactions
Ordinary shares held (in percent)		17.30%
Number of shares purchased	1,301,015
Proceeds from sale of ordinary shares, net	$ 23,000
Member board of directors
Related party transactions
Fees incurred related to related party		$ 500	$ 300	$ 1,100
NDA Group
Related party transactions
Fees incurred related to related party		$ 0	$ 100