CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Revenue:
Revenue	$ 60,370	$ 15,386	$ 48,648
Costs and expenses:
Cost of goods sold	715	6,030	2,894
Research and development (1)	201,348	173,887	141,712
Selling, general and administrative (1)	97,058	95,592	84,509
Total costs and expenses	299,121	275,509	229,115
Loss from operations	(238,751)	(260,123)	(180,467)
Income from investment in TRC, LLC (Note 7)	11,182	170
Interest expense	(10,482)	(8,547)	(1,404)
Other-than-temporary impairment loss		(8,000)
Interest and other income, net	11,966	4,789	1,312
Loss before income taxes	(226,085)	(271,711)	(180,559)
Provision for income tax benefit (expense) (Note 12)	10,561	(13,694)	(10,110)
Net loss	(215,524)	(285,405)	(190,669)
Share-based compensation expense	$ 51,313	$ 49,145	$ 41,169
Net loss per share:
Basic and diluted net loss per share (in dollars per share)	$ (3.99)	$ (5.45)	$ (4.26)
Shares used to compute basic and diluted net loss per share (in shares)	53,969	52,352	44,711
Research and development
Costs and expenses:
Share-based compensation expense	$ 25,563	$ 22,691	$ 20,202
Selling, general and administrative
Costs and expenses:
Share-based compensation expense	25,750	26,454	20,967
Product
Revenue:
Revenue	15,304	14,788	17,603
Collaborative revenue
Revenue:
Revenue	41,791	$ 598	$ 31,045
Profit sharing revenue
Revenue:
Revenue	$ 3,275