CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Revenue:
Total revenue	$ 8,319	$ 3,087
Costs and expenses:
Research and development (1)	47,765	40,565
Selling, general and administrative (1)	24,704	20,786
Total costs and expenses	73,295	61,916
Loss from operations	(64,976)	(58,829)
Interest expense	(2,137)	(2,137)
Interest and other income, net	2,170	1,030
Loss before income taxes	(64,943)	(59,936)
Provision for income taxes	144	5,383
Net loss	(65,087)	(65,319)
Share-based compensation expense	$ 13,998	$ 10,269
Net loss per share:
Basic and diluted net loss per share (in dollars per share)	$ (1.22)	$ (1.27)
Shares used to compute basic and diluted net loss per share (in shares)	53,256	51,617
Net unrealized loss on available-for-sale investments	$ (120)	$ (19)
Total comprehensive loss	(65,207)	(65,338)
Research and development
Costs and expenses:
Share-based compensation expense	6,559	5,101
Selling, general and administrative
Costs and expenses:
Share-based compensation expense	7,439	5,168
Product
Revenue:
Total revenue	3,679	3,050
Costs and expenses:
Cost of goods sold	826	565
Collaborative arrangements
Revenue:
Total revenue	$ 4,640	$ 37