Investments and Fair Value Measurements - Available for sale securities (Details) - USD ($) $ in Thousands	Mar. 31, 2018	Dec. 31, 2017
Available for sale securities:
Amortized Cost	$ 404,672	$ 370,961
Gross Unrealized Gains	1	2
Gross Unrealized Losses	(855)	(735)
Estimated Fair Value	403,818	370,228
Marketable securities
Available for sale securities:
Amortized Cost	331,488	301,906
Gross Unrealized Gains	1	2
Gross Unrealized Losses	(855)	(735)
Estimated Fair Value	330,634	301,173
U.S. government securities \| Level 1
Available for sale securities:
Amortized Cost	99,833	89,896
Gross Unrealized Losses	(372)	(342)
Estimated Fair Value	99,461	89,554
U.S. government agency securities \| Level 2
Available for sale securities:
Amortized Cost	37,187	50,891
Gross Unrealized Losses	(89)	(113)
Estimated Fair Value	37,098	50,778
Corporate notes \| Level 2
Available for sale securities:
Amortized Cost	120,945	141,226
Gross Unrealized Gains	1	2
Gross Unrealized Losses	(383)	(280)
Estimated Fair Value	120,563	140,948
Commercial paper \| Level 2
Available for sale securities:
Amortized Cost	73,523	19,893
Gross Unrealized Losses	(11)
Estimated Fair Value	73,512	19,893
Money market funds \| Level 1
Available for sale securities:
Amortized Cost	73,184	69,055
Estimated Fair Value	$ 73,184	$ 69,055

Amount before tax of unrealized gain in accumulated other comprehensive income (AOCI) on investments in debt securities classified as available-for-sale.

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Amount before tax of unrealized loss in accumulated other comprehensive income (AOCI) on investments in debt securities classified as available-for-sale.

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+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 320
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (aa)
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-Publisher FASB
-Name Accounting Standards Codification
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-Section S99
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Amount of debt securities categorized neither as held-to-maturity nor trading.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
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-URI http://asc.fasb.org/extlink&oid=6957658&loc=d3e62557-112803

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