Collaborative Arrangements - Revenue from Collaborative Arrangements (Details) - USD ($) $ in Thousands	1 Months Ended	3 Months Ended
	Feb. 28, 2018	Mar. 31, 2018	Mar. 31, 2017
Collaborative Arrangements
Total revenue from collaborative arrangements		$ 4,640	$ 37
Revenue recognized in the period from:
Amounts included in deferred revenue at the beginning of the period		16
Janssen
Collaborative Arrangements
Total revenue from collaborative arrangements	$ 4,600	4,613
Revenue recognized in the period from:
Amounts included in deferred revenue at the beginning of the period	$ 95,400
Other
Collaborative Arrangements
Total revenue from collaborative arrangements		$ 27	$ 37