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Share-Based Compensation (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended
Aug. 31, 2016
Sep. 30, 2016
Sep. 30, 2015
Sep. 30, 2016
Sep. 30, 2015
Mar. 31, 2016
Share-Based Compensation            
Share-based compensation expense   $ 9,895 $ 12,251 $ 31,129 $ 42,539  
First tranche            
Share-Based Compensation            
Share-based compensation expense   600   1,200    
Second and third tranches            
Share-Based Compensation            
Share-based compensation expense   0        
Research and development            
Share-Based Compensation            
Share-based compensation expense   4,933 6,035 15,052 20,334  
Selling, general and administrative            
Share-Based Compensation            
Share-based compensation expense   $ 4,962 $ 6,216 $ 16,077 $ 22,205  
Potential planned | Research and development            
Share-Based Compensation            
Share-based compensation expense $ 16,700          
Potential planned | Selling, general and administrative            
Share-Based Compensation            
Share-based compensation expense 22,200          
Senior management            
Share-Based Compensation            
Vesting period       5 years    
Performance-Contingent Awards - RSAs | Senior management            
Share-Based Compensation            
Shares approved for grant (in shares)           1,575,000
Performance-Contingent Awards - RSUs | Senior management            
Share-Based Compensation            
Shares approved for grant (in shares)           135,000
Maximum | Potential planned            
Share-Based Compensation            
Share-based compensation expense $ 38,900