Collaborative Arrangements - Takeda Collaborative Arrangement (Details) - USD ($) $ in Thousands	1 Months Ended	3 Months Ended		9 Months Ended
	Jun. 30, 2016	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Collaborative Arrangements
Revenue from collaborative arrangements		$ 15,174	$ 8,386	$ 30,385	$ 32,517
Takeda Collaborative Arrangement
Collaborative Arrangements
Required upfront payment	$ 15,000
Potential milestones associated with development, regulatory and commercial launch milestones for EFI	$ 110,000
Revenue from collaborative arrangements		$ 15,100