Collaborative Arrangements - Revenue from Collaborative Arrangements (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Collaborative Arrangements
Total revenue from collaborative arrangements	$ 15,174	$ 8,386	$ 30,385	$ 32,517
Mylan
Collaborative Arrangements
Total revenue from collaborative arrangements	25	25	15,076	19,149
Takeda Pharmaceuticals
Collaborative Arrangements
Total revenue from collaborative arrangements	15,075	0	15,075	0
SciClone Pharmaceuticals
Collaborative Arrangements
Total revenue from collaborative arrangements	2	2	6	2,952
R-Pharm
Collaborative Arrangements
Total revenue from collaborative arrangements	9	9	35	2,040
Trek Therapeutics
Collaborative Arrangements
Total revenue from collaborative arrangements	0	8,000	0	8,000
Other
Collaborative Arrangements
Total revenue from collaborative arrangements	$ 63	$ 350	$ 193	$ 376