CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Sep. 30, 2016	Dec. 31, 2015
Current assets:
Cash and cash equivalents	$ 86,572	$ 112,707
Short-term marketable securities	143,910	59,727
Accounts receivable, net of allowances of $1,422 and $758 at September 30, 2016 and December 31, 2015, respectively	873	1,922
Receivables from collaborative arrangements	22,713	35,232
Prepaid taxes	3,168	12,764
Other prepaid and current assets	4,319	5,115
Inventories	12,480	10,005
Total current assets	274,035	237,472
Property and equipment, net	8,832	9,873
Long-term marketable securities	58,769	42,860
Other investments	8,000	8,000
Restricted cash	833	833
Other assets	5,820	1,078
Total assets	356,289	300,116
Current liabilities:
Accounts payable	5,351	18,804
Accrued personnel-related expenses	11,887	10,866
Accrued clinical and development expenses	23,859	14,709
Other accrued liabilities	4,095	4,947
Deferred revenue	218	144
Total current liabilities	45,410	49,470
Deferred rent	4,159	4,598
Other long-term liabilities	8,847	2,983
Commitments and contingencies (Note 9)
Shareholders' equity
Preferred shares, $0.00001 par value: 230 shares authorized, no shares issued or outstanding at September 30, 2016 and December 31, 2015, respectively
Ordinary shares, $0.00001 par value: 200,000 shares authorized at September 30, 2016 and December 31, 2015; 48,092 and 37,981 shares issued and outstanding at September 30, 2016 and December 31, 2015, respectively
Additional paid-in capital	742,726	564,691
Accumulated other comprehensive income (loss)	39	(70)
Accumulated deficit	(444,892)	(321,556)
Total shareholders' equity	297,873	243,065
Total liabilities and shareholders' equity	$ 356,289	$ 300,116