CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2015	Jun. 30, 2014	Jun. 30, 2015	Jun. 30, 2014
Revenue:
Product sales	$ 2,124	$ 861	$ 3,404	$ 1,806
Revenue from collaborative arrangements	5,010	2,113	24,131	2,113
Total revenue	7,134	2,974	27,535	3,919
Costs and expenses:
Cost of goods sold	505	279	875	467
Research and development	30,377	46,283	66,396	88,006
Selling, general and administrative	21,545	13,118	43,293	32,170
Total costs and expenses	52,427	59,680	110,564	120,643
Loss from operations	(45,293)	(56,706)	(83,029)	(116,724)
Interest and other income	204	214	414	214
Loss before income taxes	(45,089)	(56,492)	(82,615)	(116,510)
Provision for income taxes	2,514	1,723	7,463	1,723
Net loss	$ (47,603)	$ (58,215)	$ (90,078)	$ (118,233)
Net loss per share:
Basic and diluted net loss per share (in dollars per share)	$ (1.42)	$ (1.83)	$ (2.71)	$ (3.72)
Shares used to compute basic and diluted net loss per share (in shares)	33,532	31,768	33,183	31,768