CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Jun. 30, 2015	Dec. 31, 2014
Current assets:
Cash and cash equivalents	$ 97,090	$ 89,215
Short-term marketable securities	113,896	165,396
Accounts receivable, net of allowances of $482 and $87 at June 30, 2015 and December 31, 2014	805	289
Receivables from collaborative arrangements	25,488	1,840
Prepaid and other current assets	10,394	6,084
Inventories	12,553	12,546
Total current assets	260,226	275,370
Marketable securities	17,794	51,399
Restricted cash	833	833
Property and equipment, net	9,609	9,663
Other assets	1,017	506
Total assets	289,479	337,771
Current liabilities:
Accounts payable	6,335	9,921
Accrued personnel-related expenses	7,793	18,156
Accrued clinical and development expenses	6,674	7,871
Other accrued liabilities	3,333	5,219
Deferred revenue	342	89
Total current liabilities	24,477	41,256
Deferred rent	4,895	5,150
Other long-term liabilities	$ 2,433	$ 1,578
Commitments and contingencies (Notes 3 and 8)
Shareholders' equity
Preferred shares, $0.00001 par value: 230 shares authorized, no shares issued or outstanding at June 30, 2015 and December 31, 2014
Ordinary shares, $0.00001 par value: 200,000 shares authorized at June 30, 2015 and December 31, 2014; 33,939 and 32,221 shares issued and outstanding at June 30, 2015 and December 31, 2014
Additional paid-in capital	$ 487,064	$ 429,206
Accumulated other comprehensive income (loss)	25	(82)
Accumulated deficit	(229,415)	(139,337)
Total shareholders' equity	257,674	289,787
Total liabilities and shareholders' equity	$ 289,479	$ 337,771