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Commitments and Contingencies (Details)
$ in Thousands
12 Months Ended
Dec. 31, 2016
USD ($)
ft²
item
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Future minimum lease payments      
2017 $ 6,121    
2018 6,305    
2019 6,494    
2020 2,758    
Thereafter 0    
Total $ 21,678    
United States      
Operating Leases      
Square feet of office and laboratory space | ft² 150,000    
Number of buildings | item 2    
Number of lease terms | item 2    
Additional lease period 5 years    
Ireland      
Operating Leases      
Square feet of office and laboratory space | ft² 1,000    
Operating Leases      
Information related to commitment and contingencies      
Rent expense $ 6,865 $ 6,522 $ 6,616
Sublease income, net $ 244 $ 186 $ 0