CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Revenue:
Product sales	$ 17,603	$ 9,408	$ 4,418
Revenue from collaborative arrangements	31,045	32,718	7,270
Total revenue	48,648	42,126	11,688
Costs and expenses:
Cost of goods sold	2,894	4,657	4,058
Research and development	141,712	129,165	168,522
Selling, general and administrative	84,509	90,203	71,647
Total costs and expenses	229,115	224,025	244,227
Loss from operations	(180,467)	(181,899)	(232,539)
Interest expense	(1,404)	0	0
Interest and other income	1,312	631	1,865
Loss before income taxes	(180,559)	(181,268)	(230,674)
Provision for income taxes	10,110	951	6,364
Net loss	(190,669)	(182,219)	(237,038)
Share-based compensation expense	$ 41,169	$ 54,050	$ 43,234
Net loss per share:
Basic and diluted net loss per share (in dollars per share)	$ (4.26)	$ (5.34)	$ (7.46)
Shares used to compute basic and diluted net loss per share (in shares)	44,711	34,150	31,755
Research and development
Costs and expenses:
Share-based compensation expense	$ 20,202	$ 25,770	$ 21,191
Selling, general and administrative
Costs and expenses:
Share-based compensation expense	$ 20,967	$ 28,280	$ 22,043