Collaborative Arrangements - Revenue from Collaborative Arrangements (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Collaborative Arrangements
Total revenue from collaborative arrangements	$ 31,045	$ 32,718	$ 7,270
Mylan
Collaborative Arrangements
Total revenue from collaborative arrangements	15,102	19,175	0
Takeda Pharmaceuticals
Collaborative Arrangements
Total revenue from collaborative arrangements	15,075	0	0
Trek Therapeutics
Collaborative Arrangements
Total revenue from collaborative arrangements	0	8,216	0
Various VIBATIV collaborative partners
Collaborative Arrangements
Total revenue from collaborative arrangements	368	5,327	7,270
Other
Collaborative Arrangements
Total revenue from collaborative arrangements	$ 500	$ 0	$ 0