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Description of Operations and Summary of Significant Accounting Policies - Related Parties (Details) - USD ($)
$ in Thousands
12 Months Ended
Mar. 17, 2016
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Related party transactions        
Proceeds from Issuance of Common Stock   $ 253,028 $ 79,017 $ 0
GSK        
Related party transactions        
Ownership percentage   18.30%    
Number of shares purchased 1,301,015      
Proceeds from Issuance of Common Stock $ 23,000      
Gunderson law firm        
Related party transactions        
Fees incurred related to related party   $ 1,100 $ 1,100 $ 1,100