Income Taxes (Tables)

12 Months Ended

Dec. 31, 2016

Income Taxes

Schedule of components of the loss before income taxes

	December 31,
(In thousands)	2016			2015			2014
Income (loss) before provision for income taxes:
Cayman Islands	$	(185,099	)	$	(107,074	)	$	(235,306	)
United States		(18,441	)		(45,960	)		5,189
Ireland		23,323			(27,013	)		—
Other		(342	)		(1,221	)		(557	)
Total	$	(180,559	)	$	(181,268	)	$	(230,674	)

Schedule of the components of the provision for income taxes

	December 31,
(In thousands)	2016			2015			2014
Provision for income taxes:
Current:
Cayman Islands	$	—		$	—		$	—
United States		9,859			883			6,223
Ireland		219			45			—
Other		32			23			141
Subtotal		10,110			951			6,364
Deferred		—			—			—
Total	$	10,110		$	951		$	6,364
Effective tax rate		(5.60	)%		(0.52	)%		(2.76	)%

Significant components of the Company's deferred tax assets and liabilities

	December 31,
(In thousands)	2016			2015
Deferred tax assets:
Net operating loss carryforwards	$	2,239		$	4,541
Research and development tax credit carryforwards		3,955			2,405
Fixed assets and acquired intangibles		6,839			7,275
Share-based compensation		13,208			10,895
Accruals		2,109			2,285
Other		476			21
Subtotal		28,826			27,422
Valuation allowance		(28,465	)		(26,822	)
Total deferred tax assets		361			600
Deferred tax liabilities:
Prepaid assets		(361	)		(600	)
Total deferred tax liabilities		(361	)		(600	)
Net deferred tax assets/liabilities	$	—		$	—

Schedule of the differences between the U.S. federal statutory income tax rate to the Company's effective tax rate

	Year Ended December 31,
	2016			2015			2014
Provision at statutory income tax rate		25.00	%		25.00	%		0.00	%
Foreign rate differential		(23.11	)		(14.62	)		(0.99	)
Change in valuation allowance		(0.89	)		(4.42	)		(2.42	)
Share-based compensation		(0.27	)		(4.15	)		—
Non-deductible executive compensation		(1.07	)		(1.09	)		—
Uncertain tax positions		(8.55	)		(3.88	)		(0.25	)
Research and development tax credit carryforwards		1.93			2.05			1.00
Other		1.36			0.59			(0.10	)
Effective tax rate		(5.60	)%		(0.52	)%		(2.76	)%

Reconciliation of unrecognized tax benefits

(In thousands)
Unrecognized tax benefits as of December 31, 2013	$	41
Gross increase in tax positions for prior years		—
Gross increase in tax positions for current year		1,018
Unrecognized tax benefits as of December 31, 2014		1,059
Gross increase in tax positions for prior years		108
Gross increase in tax positions for current year		8,031
Unrecognized tax benefits as of December 31, 2015		9,198
Gross increase in tax positions for prior years		157
Gross increase in tax positions for current year		13,899
Unrecognized tax benefits as of December 31, 2016	$	23,254