CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Dec. 31, 2016	Dec. 31, 2015
Current assets:
Cash and cash equivalents	$ 344,709	$ 112,707
Short-term marketable securities	156,387	59,727
Accounts receivable, net of allowances of $779 and $758 at December 31, 2016 and 2015, respectively	646	1,922
Receivables from collaborative arrangements	9,076	35,232
Prepaid taxes	3,060	12,764
Other prepaid and current assets	2,405	5,115
Inventories	12,220	10,005
Total current assets	528,503	237,472
Property and equipment, net	8,460	9,873
Long-term marketable securities	91,565	42,860
Other investments	8,000	8,000
Restricted cash	833	833
Other assets	1,893	1,078
Total assets	639,254	300,116
Current liabilities:
Accounts payable	1,733	18,804
Accrued personnel-related expenses	14,021	10,866
Accrued clinical and development expenses	25,064	14,709
Other accrued liabilities	8,298	4,947
Deferred revenue	152	144
Total current liabilities	49,268	49,470
Convertible senior notes, net	222,676	0
Deferred rent	3,966	4,598
Other long-term liabilities	13,113	2,983
Commitments and contingencies (Note 2, 8, 10)
Shareholders' equity
Preferred shares, $0.00001 par value: 230 shares authorized, no shares issued or outstanding at December 31, 2016 and 2015, respectively
Ordinary shares, $0.00001 par value: 200,000 shares authorized at December 31, 2016 and 2015: 52,833 and 37,981 shares issued and outstanding at December 31, 2016 and 2015, respectively	1
Additional paid-in capital	862,708	564,691
Accumulated other comprehensive loss	(253)	(70)
Accumulated deficit	(512,225)	(321,556)
Total shareholders' equity	350,231	243,065
Total liabilities and shareholders' equity	$ 639,254	$ 300,116