The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACASTI PHARMA INC CL A NEW 00430K402 1,519 620,000 SH   SOLE   620,000 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 15,235 1,322,500 SH   SOLE   1,322,500 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 1,152 100,000 SH Call SOLE   0 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 5,741 187,500 SH   SOLE   187,500 0 0
APPLIED THERAPEUTICS INC COM 03828A101 4,037 148,000 SH   SOLE   148,000 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 28,068 442,500 SH   SOLE   442,500 0 0
ARVINAS INC COM 04335A105 14,628 356,000 SH   SOLE   356,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 3,130 22,500 SH   SOLE   22,500 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 21,425 1,057,500 SH   SOLE   1,057,500 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 12,269 1,625,000 SH   SOLE   1,625,000 0 0
AXSOME THERAPEUTICS INC COM 05464T104 62,791 607,500 SH   SOLE   607,500 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 6,156 810,000 SH   SOLE   810,000 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 9,746 2,825,000 SH   SOLE   2,825,000 0 0
CHEMOCENTRYX INC COM 16383L106 1,384 35,000 SH   SOLE   35,000 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 9,304 197,500 SH   SOLE   197,500 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 8,537 387,500 SH   SOLE   387,500 0 0
IMMUNOMEDICS INC COM 452907108 3,174 150,000 SH   SOLE   150,000 0 0
INSMED INC COM PAR $.01 457669307 4,036 169,000 SH   SOLE   169,000 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 20,143 587,089 SH   SOLE   587,089 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 3,431 100,000 SH Call SOLE   0 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 18,172 656,500 SH   SOLE   656,500 0 0
IVERIC BIO INC COM 46583P102 7,808 910,000 SH   SOLE   910,000 0 0
KADMON HLDGS INC COM 48283N106 27,361 6,040,000 SH   SOLE   6,040,000 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 1,915 107,500 SH   SOLE   107,500 0 0
KARUNA THERAPEUTICS INC COM 48576A100 4,219 56,000 SH   SOLE   56,000 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 11,310 590,000 SH   SOLE   590,000 0 0
KURA ONCOLOGY INC COM 50127T109 3,300 240,000 SH   SOLE   240,000 0 0
MEDICINES CO COM 584688105 1,843 21,700 SH   SOLE   21,700 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 8,141 508,500 SH   SOLE   508,500 0 0
NEOLEUKIN THERAPEUTICS INC COM 64049K104 4,589 372,500 SH   SOLE   372,500 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 7,768 38,000 SH   SOLE   38,000 0 0
SELECTA BIOSCIENCES INC COM 816212104 5,345 2,364,204 SH   SOLE   2,364,204 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 47,555 500,000 SH Put SOLE   500,000 0 0
UNIQURE NV SHS N90064101 1,792 25,000 SH   SOLE   25,000 0 0
X4 PHARMACEUTICALS INC COM 98420X103 428 40,000 SH   SOLE   40,000 0 0
XENON PHARMACEUTICALS INC COM 98420N105 12,028 917,500 SH   SOLE   917,500 0 0
ZAFGEN INC COM 98885E103 1,110 1,000,000 SH   SOLE   1,000,000 0 0
ZYMEWORKS INC COM 98985W102 3,205 70,500 SH   SOLE   70,500 0 0