The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108 2,710 90,000 SH   SOLE   90,000 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 2,409 80,000 SH Call SOLE   0 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 2,281 92,500 SH   SOLE   92,500 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 2,287 40,000 SH Put SOLE   40,000 0 0
ALIMERA SCIENCES INC COM 016259103 1,296 974,318 SH   SOLE   974,318 0 0
AMAG PHARMACEUTICALS INC COM 00163U106 1,756 132,500 SH Put SOLE   132,500 0 0
AMICUS THERAPEUTICS INC COM 03152W109 632 43,900 SH   SOLE   43,900 0 0
ARGENX SE SPONSORED ADR 04016X101 20,394 323,000 SH   SOLE   323,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 21,272 531,000 SH   SOLE   531,000 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 49,191 1,087,104 SH   SOLE   1,087,104 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 996 55,000 SH Put SOLE   55,000 0 0
AVEO PHARMACEUTICALS INC COM 053588109 347 124,338 SH   SOLE   124,338 0 0
AVEO PHARMACEUTICALS INC COM 053588109 33 12,000 SH Call SOLE   0 0 0
AVEXIS INC COM 05366U100 5,854 52,900 SH   SOLE   52,900 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 4,419 900,000 SH   SOLE   900,000 0 0
CAS MED SYS INC COM PAR 124769209 3,973 5,160,000 SH   SOLE   5,160,000 0 0
CATALYST BIOSCIENCES INC COM NEW 14888D208 6,138 450,000 SH   SOLE   450,000 0 0
CHEMBIO DIAGNOSTICS INC COM NEW 163572209 14,115 1,721,299 SH   SOLE   1,721,299 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 1,878 80,000 SH Call SOLE   0 0 0
EDGE THERAPEUTICS INC COM 279870109 8,844 943,906 SH   SOLE   943,906 0 0
EDITAS MEDICINE INC COM 28106W103 1,229 40,000 SH Put SOLE   40,000 0 0
EDITAS MEDICINE INC COM 28106W103 1,967 64,000 SH Call SOLE   0 0 0
EVERTEC INC COM 30040P103 751 55,000 SH Put SOLE   55,000 0 0
EVOLENT HEALTH INC CL A 30050B101 5,166 420,000 SH   SOLE   420,000 0 0
EVOLENT HEALTH INC CL A 30050B101 400 32,500 SH Call SOLE   0 0 0
EXELIXIS INC COM 30161Q104 1,520 50,000 SH Call SOLE   0 0 0
FENNEC PHARMACEUTICALS INC COM 31447P100 2,505 250,000 SH   SOLE   250,000 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 1,151 52,500 SH Put SOLE   52,500 0 0
GLAUKOS CORP COM 377322102 795 31,000 SH Put SOLE   31,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 3,148 80,000 SH Call SOLE   0 0 0
IMMUNE DESIGN CORP COM 45252L103 1,069 274,100 SH   SOLE   274,100 0 0
IMMUNOMEDICS INC COM 452907108 109,080 6,750,000 SH   SOLE   6,750,000 0 0
INTEC PHARMA LTD JERUSALEM SHS M53644106 14,030 2,724,283 SH   SOLE   2,724,283 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 1,653 86,000 SH Call SOLE   0 0 0
INVITAE CORP COM 46185L103 1,383 152,300 SH   SOLE   152,300 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 31,136 3,892,000 SH   SOLE   3,892,000 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 88 11,000 SH Call SOLE   0 0 0
IRIDEX CORP COM 462684101 15,240 2,000,000 SH   SOLE   2,000,000 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 38,115 250,000 SH Put SOLE   250,000 0 0
ISHARES TR CHINA LG-CAP ETF 464287184 4,617 100,000 SH Put SOLE   100,000 0 0
JUNO THERAPEUTICS INC COM 48205A109 1,691 37,000 SH Call SOLE   0 0 0
KADMON HLDGS INC COM 48283N106 17,792 4,915,000 SH   SOLE   4,915,000 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 321 32,500 SH Put SOLE   32,500 0 0
LOXO ONCOLOGY INC COM 548862101 2,525 30,000 SH Put SOLE   30,000 0 0
MANNKIND CORP COM NEW 56400P706 400 172,500 SH Put SOLE   172,500 0 0
MEDICINES CO COM 584688105 1,094 40,000 SH Call SOLE   0 0 0
MIMEDX GROUP INC COM 602496101 631 50,000 SH Put SOLE   50,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 2,829 155,000 SH   SOLE   155,000 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 4,341 311,169 SH   SOLE   311,169 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 35 2,500 SH Put SOLE   2,500 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 646 46,300 SH Call SOLE   0 0 0
NABRIVA THERAPEUTICS PLC SHS G63637105 3,468 580,000 SH   SOLE   580,000 0 0
NEKTAR THERAPEUTICS COM 640268108 1,792 30,000 SH Put SOLE   30,000 0 0
NEKTAR THERAPEUTICS COM 640268108 2,150 36,000 SH Call SOLE   0 0 0
NEOS THERAPEUTICS INC COM 64052L106 255 25,000 SH Put SOLE   25,000 0 0
NEOS THERAPEUTICS INC COM 64052L106 1,178 115,500 SH Call SOLE   0 0 0
ONCOBIOLOGICS INC COM 68235M105 38 29,082 SH   SOLE   29,082 0 0
ORASURE TECHNOLOGIES INC COM 68554V108 1,886 100,000 SH Put SOLE   100,000 0 0
ROCKWELL MED INC COM 774374102 2,561 440,000 SH Put SOLE   440,000 0 0
SEATTLE GENETICS INC COM 812578102 1,605 30,000 SH Put SOLE   30,000 0 0
SEATTLE GENETICS INC COM 812578102 4,280 80,000 SH Call SOLE   0 0 0
SPARK THERAPEUTICS INC COM 84652J103 514 10,000 SH Put SOLE   10,000 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 29,705 350,000 SH Put SOLE   350,000 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 1,638 105,000 SH Call SOLE   0 0 0
TELADOC INC COM 87918A105 1,394 40,000 SH Put SOLE   40,000 0 0
TG THERAPEUTICS INC COM 88322Q108 82 10,000 SH Call SOLE   0 0 0
TRANSENTERIX INC COM NEW 89366M201 203 105,000 SH Put SOLE   105,000 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 2,133 46,000 SH Call SOLE   0 0 0
VALEANT PHARMACEUTICALS INTL COM 91911K102 2,078 100,000 SH Call SOLE   0 0 0
VERACYTE INC COM 92337F107 21,517 3,295,111 SH   SOLE   3,295,111 0 0
VIEWRAY INC COM 92672L107 17,739 1,915,654 SH   SOLE   1,915,654 0 0
VIEWRAY INC COM 92672L107 1,111 120,000 SH Call SOLE   0 0 0
VIVEVE MED INC COM NEW 92852W204 2,154 433,419 SH   SOLE   433,419 0 0
ZOGENIX INC COM NEW 98978L204 12,015 300,000 SH   SOLE   300,000 0 0