The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108 6,404 170,000 SH   SOLE   170,000 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 2,637 70,000 SH Call SOLE   0 0 0
ACCELERATE DIAGNOSTICS INC COM 00430H102 1,347 60,000 SH Put SOLE   60,000 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 1,451 58,525 SH   SOLE   58,525 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 2,104 15,000 SH   SOLE   15,000 0 0
ALIMERA SCIENCES INC COM 016259103 1,315 974,318 SH   SOLE   974,318 0 0
AMAG PHARMACEUTICALS INC COM 00163U106 923 50,000 SH Put SOLE   50,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 4,524 300,000 SH   SOLE   300,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 2,277 151,000 SH Call SOLE   0 0 0
ARGENX SE SPONSORED ADR 04016X101 4,890 216,255 SH   SOLE   216,255 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 18,125 500,000 SH   SOLE   500,000 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 34,920 1,000,000 SH   SOLE   1,000,000 0 0
AXOVANT SCIENCES LTD COM G0750W104 140 20,300 SH Call SOLE   0 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 5,221 996,300 SH   SOLE   996,300 0 0
CAS MED SYS INC COM PAR 124769209 4,686 5,093,276 SH   SOLE   5,093,276 0 0
CENTENE CORP DEL COM 15135B101 1,935 20,000 SH Put SOLE   20,000 0 0
CHEMBIO DIAGNOSTICS INC COM NEW 163572209 10,672 1,721,299 SH   SOLE   1,721,299 0 0
CLOVIS ONCOLOGY INC COM 189464100 6,592 80,000 SH Call SOLE   0 0 0
COMBIMATRIX CORPORATION COM PAR 20009T501 839 111,912 SH   SOLE   111,912 0 0
COMBIMATRIX CORPORATION *W EXP 03/18/202 20009T147 1,411 564,200 SH   SOLE   564,200 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 8,148 192,000 SH   SOLE   192,000 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 382 9,000 SH Call SOLE   0 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 8,488 200,000 SH Put SOLE   200,000 0 0
EDGE THERAPEUTICS INC COM 279870109 13,449 1,253,394 SH   SOLE   1,253,394 0 0
EVERTEC INC COM 30040P103 1,090 68,800 SH Put SOLE   68,800 0 0
EVOLENT HEALTH INC CL A 30050B101 8,010 450,000 SH   SOLE   450,000 0 0
EVOLENT HEALTH INC CL A 30050B101 1,477 83,000 SH Call SOLE   0 0 0
FENNEC PHARMACEUTICALS INC COM 31447P100 2,773 250,000 SH   SOLE   250,000 0 0
GLAUKOS CORP COM 377322102 990 30,000 SH Put SOLE   30,000 0 0
GOGO INC COM 38046C109 1,594 135,000 SH Put SOLE   135,000 0 0
IMMUNOMEDICS INC COM 452907108 94,193 6,737,706 SH   SOLE   6,737,706 0 0
IMMUNOMEDICS INC COM 452907108 9,332 667,500 SH Call SOLE   0 0 0
INTEC PHARMA LTD JERUSALEM SHS M53644106 24,382 2,724,283 SH   SOLE   2,724,283 0 0
INVITAE CORP COM 46185L103 4,947 528,000 SH   SOLE   528,000 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 26,597 3,431,809 SH   SOLE   3,431,809 0 0
IRIDEX CORP COM 462684101 18,740 2,000,000 SH   SOLE   2,000,000 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 68,904 465,000 SH Put SOLE   465,000 0 0
ISHARES TR CHINA LG-CAP ETF 464287184 4,404 100,000 SH Put SOLE   100,000 0 0
JOHNSON & JOHNSON COM 478160104 5,850 45,000 SH Put SOLE   45,000 0 0
KADMON HLDGS INC COM 48283N106 11,167 3,333,333 SH   SOLE   3,333,333 0 0
LANNET INC COM 516012101 2,352 127,500 SH Put SOLE   127,500 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 492 40,000 SH Put SOLE   40,000 0 0
MANNKIND CORP COM NEW 56400P706 760 350,000 SH Put SOLE   350,000 0 0
MIMEDX GROUP INC COM 602496101 832 70,000 SH Put SOLE   70,000 0 0
NABRIVA THERAPEUTICS PLC SHS G63637105 3,276 400,000 SH   SOLE   400,000 0 0
NIGHTSTAR THERAPEUTICS PLC ADR 65413A101 1,920 100,000 SH   SOLE   100,000 0 0
ONCOBIOLOGICS INC COM 68235M105 40 29,082 SH   SOLE   29,082 0 0
ONCOBIOLOGICS INC *W EXP 02/18/201 68235M113 12 96,833 SH   SOLE   96,833 0 0
ONCOBIOLOGICS INC *W EXP 05/18/201 68235M121 5 96,833 SH   SOLE   96,833 0 0
OTONOMY INC COM 68906L105 57 17,500 SH Call SOLE   0 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 1,081 20,000 SH Put SOLE   20,000 0 0
QUOTIENT LTD SHS G73268107 2,806 569,145 SH   SOLE   569,145 0 0
RA PHARMACEUTICALS INC COM 74933V108 1,044 71,500 SH   SOLE   71,500 0 0
ROCKWELL MED INC COM 774374102 2,140 250,000 SH Put SOLE   250,000 0 0
SEATTLE GENETICS INC COM 812578102 2,176 40,000 SH Call SOLE   0 0 0
SEATTLE GENETICS INC COM 812578102 3,809 70,000 SH Put SOLE   70,000 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 48,479 560,000 SH Put SOLE   560,000 0 0
TELADOC INC COM 87918A105 995 30,000 SH Put SOLE   30,000 0 0
TOCAGEN INC COM 888846102 3,129 251,112 SH   SOLE   251,112 0 0
VERACYTE INC COM 92337F107 28,898 3,295,111 SH   SOLE   3,295,111 0 0
VIEWRAY INC COM 92672L107 7,672 1,331,983 SH   SOLE   1,331,983 0 0
VIVEVE MED INC COM NEW 92852W204 4,335 827,340 SH   SOLE   827,340 0 0
ZOGENIX INC COM NEW 98978L204 8,763 250,000 SH   SOLE   250,000 0 0
ZOGENIX INC COM NEW 98978L204 5,608 160,000 SH Put SOLE   160,000 0 0