<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <schemaVersion>X0202</schemaVersion>
<headerData>
    <submissionType>SCHEDULE 13G</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: Hezbay Holdings LLC -->
          <cik>0002058272</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <securitiesClassTitle>COMMON STOCK, $0.0001 PAR VALUE PER SHARE</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>07/13/2026</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001582554</issuerCik>
        <issuerName>MATINAS BIOPHARMA HOLDINGS INC.</issuerName>
        <issuerCusips>
          <issuerCusipNumber>576810303</issuerCusipNumber>
        </issuerCusips>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>1545 Route 206 South</com:street1>
          <com:street2>Suite 302</com:street2>
          <com:city>Bedminster</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07921</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Hezbay Holdings LLC</reportingPersonName>
      <citizenshipOrOrganization>NY</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>1306488.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>1306488.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>1306488.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>Y</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>9.54</classPercent>
      <typeOfReportingPerson>OO</typeOfReportingPerson>
      <comments>Note to 6, 8, 9 and 11: Based on 13,692,796 Common Shares issued and outstanding as of July 10, 2026.  Note to 10: The aggregate amount in Row 9 excludes the Common Shares purchasable pursuant to the Preferred Shares and Warrants owned by the Reporting Person which contain a contractually stipulated 4.99% ownership restriction.</comments>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>MATINAS BIOPHARMA HOLDINGS INC.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>1545 Route 206 South, Suite 302, Bedminster, NJ 07921</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>Hezbay Holdings LLC</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>23 Tammy Road, Spring Valley, New York 10977</principalBusinessOfficeOrResidenceAddress>
        <citizenship>New York</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>1,306,488.00</amountBeneficiallyOwned>
        <classPercent>9.54</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>1,306,488.00</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>0.00</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>1,306,488.00</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>0.00</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>Hezbay Holdings LLC</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Ari Kluger</signature>
        <title>Ari Kluger, Sole Member of Hezbay Holdings LLC</title>
        <date>07/14/2026</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
</edgarSubmission>
