BOOKING HOLDINGS INC COM 09857L108 10519 5611 SH SOLE 5611 0 0 ALLOGENE THERAPEUTICS INC COM 019770106 14289 532166 SH SOLE 532166 0 0 COSTAR GROUP INC COM 22160N109 66704 120392 SH SOLE 120392 0 0 EDITAS MEDICINE INC COM 28106W103 4593 185668 SH SOLE 185668 0 0 ENTERA BIO LTD SHS M40527109 697 203190 SH SOLE 203190 0 0 FACEBOOK INC CL A 30303M102 12845 66553 SH SOLE 66553 0 0 GRITSTONE ONCOLOGY INC COM 39868T105 2167 194499 SH SOLE 194499 0 0 GOOSEHEAD INS INC COM CL A 38267D109 3324 69533 SH SOLE 69533 0 0 NANTKWEST INC COM 63016Q102 568 556453 SH SOLE 556453 0 0 PLAYA HOTELS & RESORTS NV SHS N70544106 2313 300000 SH SOLE 300000 0 0 SABINE ROYALTY TR UNIT BEN INT 785688102 16157 335564 SH SOLE 335564 0 0 SIENNA BIOPHARMACEUTICALS IN COM 82622H108 257 295613 SH SOLE 295613 0 0 SORRENTO THERAPEUTICS INC COM NEW 83587F202 1110 415765 SH SOLE 415765 0 0 UROGEN PHARMA LTD COM M96088105 18774 522361 SH SOLE 522361 0 0 BEYOND MEAT INC CALL 08862E909 1120 27072 SH Call DFND 27072 0 0 VANECK VECTORS ETF TR PUT 92189F156 192 80000 SH Put DFND 80000 0 0 UNITED STATES NATL GAS FUND CALL 912318900 3 4000 SH Call DFND 4000 0 0 UNITED STATES NATL GAS FUND PUT 912318950 1248 534400 SH Put DFND 534400 0 0 SELECT SECTOR SPDR TR CALL 81369Y906 3325 423500 SH Call DFND 423500 0 0 SELECT SECTOR SPDR TR PUT 81369Y956 2149 289800 SH Put DFND 289800 0 0 SELECT SECTOR SPDR TR CALL 81369Y906 320 135200 SH Call DFND 135200 0 0 NANTHEALTH INC COM 630104107 43 81870 SH DFND 81870 0 0 UROGEN PHARMA LTD COM M96088105 11537 321004 SH DFND 321004 0 0 SPDR GOLD TRUST GOLD SHS 78463V107 17934 134643 SH DFND 134643 0 0 ISHARES TR IBOXX HI YD ETF 464288513 6479 74648 SH DFND 74648 0 0 ISHARES TR IBOXX INV CP ETF 464287242 9579 77237 SH DFND 77237 0 0 ISHARES TR JPMORGAN USD EMG 464288281 7932 70289 SH DFND 70289 0 0 VANGUARD WHITEHALL FDS INC HIGH DIV YLD 921946406 2830 32391 SH DFND 32391 0 0 ISHARES TR 20 YR TR BD ETF 464287432 3397 25630 SH DFND 25630 0 0 CAMECO CORP COM 13321L108 4013 374039 SH DFND 374039 0 0 ISHARES TR NATIONAL MUN ETF 464288414 4582 40600 SH DFND 40600 0 0 UNITED STATES NATL GAS FUND UNIT PAR 912318300 103 5200 SH DFND 5200 0 0