BOOKING HOLDINGS INC COM 09857L108 8133 4661 SH SOLE 4661 0 0 COSTAR GROUP INC COM 22160N109 62254 133472 SH SOLE 133472 0 0 EDITAS MEDICINE INC COM 28106W103 4540 185668 SH SOLE 185668 0 0 ENTERA BIO LTD SHS M40527109 853 203190 SH SOLE 203190 0 0 FACEBOOK INC CL A 30303M102 7010 42053 SH SOLE 42053 0 0 GRITSTONE ONCOLOGY INC COM 39868T105 2587 194499 SH SOLE 194499 0 0 LPL FINANCIAL HOLDINGS INC COM 50212V100 7084 101712 SH SOLE 101712 0 0 NANTHEALTH INC COM 630104107 109 118503 SH SOLE 118503 0 0 NANTKWEST INC COM 63016Q102 879 556453 SH SOLE 556453 0 0 PLAYA HOTELS & RESORTS NV SHS N70544106 2289 300000 SH SOLE 300000 0 0 SABINE ROYALTY TRUST UNIT BEN INT 785688102 15509 335564 SH SOLE 335564 0 0 SIENNA BIOPHARMACEUTICALS IN COM 82622H108 686 295613 SH SOLE 295613 0 0 SORRENTO THERAPEUTICS INC COM NEW 83587F202 1975 415765 SH SOLE 415765 0 0 UROGEN PHARMA LTD COM M96088105 19504 527999 SH SOLE 527999 0 0 BARCLAYS BK PLC CALL 06746P901 186 75520 SH DFND 75520 0 0 UNITED STATES NATL GAS FUND CALL 912318900 30 30000 SH DFND 30000 0 0 NANTHEALTH INC COM 630104107 75 81870 SH DFND 81870 0 0 UROGEN PHARMA LTD COM M96088105 9272 251004 SH DFND 251004 0 0 SPDR GOLD TRUST GOLD SHS 78463V107 317 2600 SH DFND 2600 0 0 ISHARES TR IBOXX HI YD ETF 464288513 8588 99752 SH DFND 99752 0 0 ISHARES TR IBOXX INV CP ETF 464287242 7135 60107 SH DFND 60107 0 0 ISHARES TR JPMORGAN USD EMG 464288281 6218 56731 SH DFND 56731 0 0 VANGUARD WHITEHALL FDS INC HIGH DIV YLD 921946406 2766 32286 SH DFND 32286 0 0 ISHARES TR 20 YR TR BD ETF 464287432 2623 20792 SH DFND 20792 0 0