ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 4004 37848 SH SOLE 37848 0 0 COSTAR GROUP INC COM 22160N109 54227 250437 SH SOLE 250437 0 0 CURRENCYSHS JAPANESE YEN TR JAPANESE YEN 23130A102 3018 31699 SH DFND 31699 0 0 EDITAS MEDICINE INC COM 28106W103 631 46775 SH SOLE 46775 0 0 ISHARES TR 20 YR TR BD ETF 464287432 662 4832 SH SOLE 4832 0 0 ISHARES TR IBOXX HI YD ETF 464288513 2836 32796 SH DFND 32796 0 0 ISHARES TR JP MOR EM MK ETF 464288281 2565 22066 SH DFND 22066 0 0 ISHARES TR NASDQ BIOTEC ETF 464287556 2696 9315 SH DFND 9315 0 0 ISHARES TR 20 YR TR BD ETF 464287432 3496 25515 SH DFND 25515 0 0 ISHARES TR CALL 464287900 5671 50830 SH Call DFND 50830 0 0 ISHARES TR PUT 464287954 1479 39505 SH Put DFND 39505 0 0 ISHARES TR CALL 464287904 1000 26710 SH Call DFND 26710 0 0 ISHARES TR PUT 464287950 5121 45900 SH Put DFND 45900 0 0 ISHARES TR PUT 464287904 986 25950 SH Put DFND 25950 0 0 ISHARES TR PUT 464287955 4641 78480 SH Put DFND 78480 0 0 KITE PHARMA INC COM 49803L109 131723 2358084 SH SOLE 2358084 0 0 LPL FINL HLDGS INC COM 50212V100 6139 206647 SH SOLE 206647 0 0 MIMEDX GROUP INC COM 602496101 9270 1080365 SH SOLE 1080365 0 0 NANTHEALTH INC COM 630104107 1547 117623 SH SOLE 117623 0 0 NANTHEALTH INC COM 630104107 1553 118129 SH DFND 118129 0 0 NANTKWEST INC COM 63016Q102 34897 4485495 SH SOLE 4485495 0 0 POWERSHARES DB CMDTY IDX TRA UNIT BEN INT 73935S105 919 61220 SH DFND 61220 0 0 POWERSHARES QQQ TRUST UNIT SER 1 73935A104 1916 16137 SH DFND 16137 0 0 POWERSHARES QQQ TRUST CALL 73935A904 17915 150905 SH Call DFND 150905 0 0 RYANAIR HLDGS PLC SPONSORED ADR NE 783513203 86415 5654679 SH SOLE 5654679 0 0 SPDR S&P 500 ETF TR PUT 78462F953 6781 31350 SH Put DFND 31350 0 0 SPDR S&P 500 ETF TR CALL 78462F903 2563 11850 SH Call DFND 11850 0 0 SORRENTO THERAPEUTICS INC COM NEW 83587F202 20714 2676193 SH SOLE 2676193 0 0 SORRENTO THERAPEUTICS INC COM NEW 83587F202 957 123597 SH DFND 123597 0 0 UNITED STATES NATL GAS FUND UNIT PAR $0.001 912318201 1010 120821 SH DFND 120821 0 0 WISDOMTREE TR JAPN HEDGE EQT 97717W851 858 20000 SH SOLE 20000 0 0