ADVERUM BIOTECHNOLOGIES INC COM 00773U108 47 15000 SH SOLE 15000 0 0 COMMUNICATIONS SALES & LEAS IN COM 20341J104 4364 151000 SH SOLE 151000 0 0 COSTAR GROUP INC COM 22160N109 55067 251837 SH SOLE 251837 0 0 EDITAS MEDICINE INC COM 28106W103 1149 47075 SH SOLE 47075 0 0 EDITAS MEDICINE INC COM 28106W103 310 12725 SH DFND 12725 0 0 HILTON WORLDWIDE HLDGS INC COM 43300A104 11378 505000 SH SOLE 505000 0 0 INTELLIA THERAPEUTICS INC COM 45826J105 534 25000 SH DFND 25000 0 0 ISHARES TR 20 YR TR BD ETF 464287432 669 4832 SH SOLE 4832 0 0 ISHARES TR CALL 464287906 1243 4830 SH Call DFND 4830 0 0 ISHARES TR PUT 464288953 1140 13589 SH Put DFND 13589 0 0 ISHARES TR CALL 464287900 3444 30573 SH Call DFND 30573 0 0 ISHARES TR PUT 464287950 223 1983 SH Put DFND 1983 0 0 ISHARES TR PUT 464287955 776 6790 SH Put DFND 6790 0 0 ISHARES TR PUT 464288953 1139 13575 SH Put SOLE 13575 0 0 ISHARES TR PUT 464287950 222 1975 SH Put SOLE 1975 0 0 ISHARES TR CALL 464287900 3436 30500 SH Call SOLE 30500 0 0 ISHARES TR PUT 464287955 776 6790 SH Put SOLE 6790 0 0 KITE PHARMA INC COM 49803L109 117904 2358084 SH SOLE 2358084 0 0 LPL FINL HLDGS INC COM 50212V100 4612 206647 SH SOLE 206647 0 0 MIMEDX GROUP INC COM 602496101 8621 1080365 SH SOLE 1080365 0 0 NANTHEALTH INC COM 630104107 1470 117623 SH SOLE 117623 0 0 NANTHEALTH INC COM 630104107 1538 123025 SH DFND 123025 0 0 NANTKWEST INC COM 63016Q102 27900 4485495 SH SOLE 4485495 0 0 NANTKWEST INC COM 63016Q102 62 10000 SH DFND 10000 0 0 RYANAIR HLDGS PLC SPONSORED ADR NE 783513203 86415 5654679 SH SOLE 5654679 0 0 SORRENTO THERAPEUTICS INC COM NEW 83587F202 14986 2676193 SH SOLE 2676193 0 0 SORRENTO THERAPEUTICS INC COM NEW 83587F202 692 123597 SH DFND 123597 0 0 SPDR S&P 500 ETF TR CALL 78462F903 432 2063 SH Call DFND 2063 0 0 SPDR S&P 500 ETF TR CALL 78462F903 432 2063 SH Call SOLE 2063 0 0 WISDOMTREE TR JAPN HEDGE EQT 97717W851 776 20000 SH SOLE 20000 0 0