Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Operating activities:
Net loss	$ (50,828)	$ (37,873)
Items not involving cash:
Depreciation	751	427
Deferred income tax expense (recovery)	154	(21)
Stock-based compensation	8,822	4,669
Unrealized foreign exchange loss	492	11
Unrealized fair value loss on marketable securities	4,650	92
Changes in operating assets and liabilities:
Accounts receivable	235	(608)
Prepaid expenses and other current assets	439	(349)
Accounts payable and accrued expenses	(11)	484
Deferred revenue		(617)
Net cash used in operating activities	(35,296)	(33,785)
Investing activities:
Purchases of property, plant and equipment	(756)	(1,313)
Purchases of marketable securities	(141,638)	(122,279)
Proceeds from marketable securities	94,823	76,680
Net cash used in investing activities	(47,571)	(46,912)
Financing activities:
Issuance of common shares and pre-funded warrants, net of issuance costs (note 7a and note 7c)	277,766	118,615
Issuance of common shares pursuant to exercise of stock options		217
Net cash provided by financing activities	277,766	118,832
Effect of exchange rate changes on cash and cash equivalents	(600)	(214)
Increase in cash and cash equivalents	194,299	37,921
Cash and cash equivalents, beginning of period	175,688	45,009
Cash and cash equivalents, end of period	369,987	82,930
Supplemental disclosures:
Interest received	3,509	1,537
Cash paid for operating lease	410	412
Supplemental disclosures of non-cash transactions:
Fair value of stock options exercised on a cashless basis	$ 2,409	1,324
Increase in operating lease liability and accounts receivable related to lease incentives claimed in the period		$ 493