Consolidated Statements of Shareholders' Equity (Unaudited) - USD ($) $ in Thousands	Total		Convertible Preferred Shares [Member]	Common Shares [Member]	Additional Paid-in Capital [Member]	Accumulated Deficit [Member]	Accumulated Other Comprehensive Loss [Member]	[1]
Balance at Dec. 31, 2020	$ 171,355		$ 7,732	$ 397,748	$ 45,357	$ (278,492)	$ (990)
Balance (in Shares) at Dec. 31, 2020			1,016,000	35,012,125
Net loss	(15,764)					(15,764)
Issuance of common shares and pre-funded warrants, net of issuance costs (note 7a and note 7c)	118,615			$ 99,846	18,769
Issuance of common shares and pre-funded warrants, net of issuance costs (note 7a and note 7c) (in shares)				5,868,135
Stock-based compensation expense	1,965				1,965
Issued pursuant to exercise of stock options	$ 106			$ 740	(634)
Issued pursuant to exercise of of stock options (in Shares)	122,403	[2]		82,455
Balance at Mar. 31, 2021	$ 276,277		$ 7,732	$ 498,334	65,457	(294,256)	(990)
Balance (in Shares) at Mar. 31, 2021			1,016,000	40,962,715
Balance at Dec. 31, 2021	550,033		$ 7,732	$ 783,170	117,495	(357,374)	(990)
Balance (in Shares) at Dec. 31, 2021			1,016,000	51,634,752
Net loss	(19,670)					(19,670)
Issuance of common shares and pre-funded warrants, net of issuance costs (note 7a and note 7c)	7,876			$ 7,876
Issuance of common shares and pre-funded warrants, net of issuance costs (note 7a and note 7c) (in shares)				258,986
Conversion of preferred shares to common shares (note 7b)			$ (7,732)	$ 7,732
Conversion of preferred shares to common shares (note 7b) (in shares)			(1,016,000)	1,016,000
Stock-based compensation expense	$ 3,614				3,614
Issued pursuant to exercise of stock options				$ 1,529	(1,529)
Issued pursuant to exercise of of stock options (in Shares)	219,107	[2]		149,311
Balance at Mar. 31, 2022	$ 541,853		$ 0	$ 800,307	$ 119,580	$ (377,044)	$ (990)
Balance (in Shares) at Mar. 31, 2022			0	53,059,049

[1] The accumulated other comprehensive loss is entirely related to historical cumulative translation adjustments from the application of U.S. dollar reporting when the functional currency of the Company was the Canadian dollar.

[2] During the three months ended March 31, 2022, no stock options were exercised for cash (2021 – 46,296). In the same period, the Company issued 149,311 (2021 – 36,159) common shares for the cashless exercise of 219,107  (2021 – 76,107) stock options.