Share Capital (Details) - USD ($) $ / shares in Units, $ in Thousands	1 Months Ended									8 Months Ended	12 Months Ended
	Oct. 31, 2021	Sep. 30, 2021	Mar. 31, 2021	Aug. 31, 2020	Jun. 30, 2020	Feb. 29, 2020	Jan. 31, 2020	Sep. 30, 2019	Mar. 31, 2018	Oct. 31, 2021	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Share Capital [Line Items]
Amount offered for issuance of common stock											$ 447,283	$ 102,456
Warrants outstanding to purchase common stock											2,775,996
Options granted											1,775,450	1,482,250
Options Outstanding Weighted Average Remaining Contractual Life in Years											7 years 3 months 3 days
Options Exercisable Weighted Average Remaining Contractual Life in Years											5 years 9 months 14 days
Aggregate fair value of options vested											$ 8,271	$ 3,698
Unrecognized stock-based compensation cost											$ 24,210
Unrecognized stock-based compensation expected to be recognized over a period											2 years 9 months 10 days
Warrants exercise description	The Company may not affect the exercise of any Pre-Funded Warrant, and a holder will not be entitled to exercise any portion of any Pre-Funded Warrant that, upon giving effect to such exercise, would cause: (i) the aggregate number of common shares beneficially owned by such holder, together with its affiliates, to exceed 4.99% of the total number of common shares outstanding immediately after giving effect to the exercise; or (ii) the combined voting power of the Company’s securities beneficially owned by such holder, together with its affiliates, to exceed 4.99% of the combined voting power of all of the Company’s securities immediately outstanding after giving effect to the exercise, which percentage may be changed at the holder’s election to a higher or lower percentage not in excess of 19.99% upon at least 61 days’ notice to the Company.		The Company may not affect the exercise of any Pre-Funded Warrant, and a holder will not be entitled to exercise any portion of any Pre-Funded Warrant that, upon giving effect to such exercise, would cause: (i) the aggregate number of common shares beneficially owned by such holder, together with its affiliates, to exceed 4.99% of the total number of common shares outstanding immediately after giving effect to the exercise; or (ii) the combined voting power of the Company’s securities beneficially owned by such holder, together with its affiliates, to exceed 4.99% of the combined voting power of all of the Company’s securities immediately outstanding after giving effect to the exercise, which percentage may be changed at the holder’s election to a higher or lower percentage not in excess of 19.99% upon at least 61 days’ notice to the Company.
Amended and Restated Stock Option Plan [Member]
Share Capital [Line Items]
Vesting period											4 years
Maximum term of each option exercised											10 years
Options granted											0
2019 Inducement Plan [Member]
Share Capital [Line Items]
Options granted								0
Common shares reserved for issuance								400,000
Amended and Restated 2014 Plan [Member]
Share Capital [Line Items]
Vesting period					4 years
Maximum term of each option exercised					10 years
Common shares reserved for issuance					4,000,000						2,416,591
Number of restricted share awards, restricted share unit awards or performance awards available for issue					1,000,000
Common Shares [Member]
Share Capital [Line Items]
Shares issued											16,143,472	6,759,187
Amount offered for issuance of common stock											$ 381,567	$ 102,456
Common Shares [Member] | Neurocrine Collaboration Agreement [Member]
Share Capital [Line Items]
Amount offered for issuance of common stock		$ 5,500
Shares issued		275,337
Aggregate purchase price per share		$ 19.9755
Common stock purchase price premium at fair value		$ 770
Jefferies and Stifel [Member] | Underwritten Public Offering [Member]
Share Capital [Line Items]
Amount offered for issuance of common stock			$ 107,922
Shares issued			5,135,135
Shares price			$ 18.50
Warrants outstanding to purchase common stock			1,081,081
Warrants issued price per pre funded warrant			$ 18.4999
Warrants exercise price per common share			$ 0.0001
Jefferies and Stifel [Member] | At-The-Market Equity Offering [Member]
Share Capital [Line Items]
Amount offered for issuance of common stock							$ 37,796				$ 10,693		$ 10,729
Jefferies and Stifel [Member] | At-The-Market Equity Offering [Member] | Maximum [Member]
Share Capital [Line Items]
Amount offered for issuance of common stock				$ 100,000
Jefferies and Stifel [Member] | At-The-Market Equity Offering [Member] | Common Shares [Member]
Share Capital [Line Items]
Shares issued							2,446,687				733,000		805,643
Jefferies and Stifel [Member] | Over Allotment [Member]
Share Capital [Line Items]
Shares issued			810,810
Jefferies, Stifel and Guggenheim Securities, LLC [Member] | Underwritten Public Offering [Member]
Share Capital [Line Items]
Amount offered for issuance of common stock						$ 8,395	$ 56,265
Jefferies, Stifel and Guggenheim Securities, LLC [Member] | Underwritten Public Offering [Member] | Common Shares [Member]
Share Capital [Line Items]
Shares issued						562,500	3,750,000
Shares price							$ 16.00
Jefferies LLC SVB Leerink LLC and Stifel Nicolaus Company Incorporated [Member] | Underwritten Public Offering [Member]
Share Capital [Line Items]
Amount offered for issuance of common stock	$ 323,938
Shares issued	10,000,000
Shares price	$ 29.50									$ 29.50
Warrants outstanding to purchase common stock	1,694,915									1,694,915
Warrants issued price per pre funded warrant	$ 29.4999									$ 29.4999
Warrants exercise price per common share	$ 0.0001									$ 0.0001
Sale proceeds from issuance of pre funded warrants										$ 65,716
Number of warrants exercised											0
Jefferies LLC SVB Leerink LLC and Stifel Nicolaus Company Incorporated [Member] | Over Allotment [Member]
Share Capital [Line Items]
Shares issued	1,525,423
BVF Partners L.P [Member] | Exchange Agreement [Member] | Series1 Preferred Shares
Share Capital [Line Items]
Preferred shares convertible into common shares									one-for-one
Common shares issued on conversion of preferred stock									1
Maximum beneficial ownership limitation percentage for conversion of common stock issued and outstanding									9.99%
Maximum beneficial ownership limitation upon notice, percentage for conversion of common stock issued and outstanding									19.99%
Maximum beneficial percentage hold for conversion of number Of common stock issued and outstanding									5.00%
Minimum beneficial percentage hold for conversion of number Of common stock issued and outstanding.									5.00%