Consolidated Statement of Shareholders' Equity - USD ($) $ in Thousands		Total		Convertible Preferred Shares [Member]	Common Shares [Member]	Additional Paid-in Capital [Member]	Accumulated Deficit [Member]	Accumulated Other Comprehensive Loss [Member]	[1]
Balance at Dec. 31, 2017		$ 35,934			$ 173,841	$ 36,471	$ (173,388)	$ (990)
Balance (in Shares) at Dec. 31, 2017					17,998,420
Net loss		(34,497)					(34,497)
Issuance of common shares, net of issuance costs (note 11a)		102,850			$ 102,850
Issuance of common shares, net of issuance costs (note 11a) (in shares)					9,540,000
Issued (cancelled) pursuant to exchange agreement (note 11d)				$ 21,825	$ (21,825)
Issued (cancelled) pursuant to exchange agreement (note 11d) (in Shares)				2,868,000	(2,868,000)
Conversion of preferred shares to common shares (note 11d)				$ (14,093)	$ 14,093
Conversion of preferred shares to common shares (note 11d) (in shares)				(1,852,000)	1,852,000
Cancelled pursuant to termination of collaboration agreement (note 13c)		(4,470)			$ (4,470)
Cancelled pursuant to termination of collaboration agreement (in Shares)					(1,000,000)
Stock-based compensation expense		2,652				2,652
Issued pursuant to exercise of stock options and warrants		288			$ 1,434	(1,146)
Issued pursuant to exercise of stock options and warrants (in shares)					228,301
Issuance of warrants		$ 538				538
Issued pursuant to exercise of stock options (in Shares)	[2]	251,163
Balance at Dec. 31, 2018		$ 103,295		$ 7,732	$ 265,923	38,515	(207,885)	(990)
Balance (in Shares) at Dec. 31, 2018				1,016,000	25,750,721
Cumulative effect of accounting change (note 4a)		(175)					(175)
Net loss		(41,595)					(41,595)
Issuance of common shares, net of issuance costs (note 11a)		27,396			$ 27,396
Issuance of common shares, net of issuance costs (note 11a) (in shares)					2,214,490
Stock-based compensation expense		2,934				2,934
Issued pursuant to exercise of stock options		$ 122			$ 925	(803)
Issued pursuant to exercise of stock options (in Shares)		266,157	[2]		174,017
Balance at Dec. 31, 2019		$ 91,977		$ 7,732	$ 294,244	$ 40,646	$ (249,655)	$ (990)
Balance (in Shares) at Dec. 31, 2019				1,016,000	28,139,228

[1] The accumulated other comprehensive loss is entirely related to historical cumulative translation adjustments from the application of U.S. dollar reporting when the functional currency of the Company was the Canadian dollar.

[2] During the year ended December 31, 2019, 36,174 (2018 – 49,502) stock options were exercised for the same number of common shares in exchange for cash. In the same period, the Company issued 137,843 (2018 – 106,474) common shares for the cashless exercise of 229,983 (2018 – 201,661) stock options.